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Eric Bonsu

Assistant Professor

Center for Natural Sciences, Mathematics and Nursing, Room 2174 301-860-3348

Education

2005

Ph.D. Pharmacy/ Medicinal Chemistry

Advisor: Prof.  V. Nair

Pharmaceutical and Biomedical Sciences

College of Pharmacy, University of Georgia

Athens GA 30602

 

2002

Ph.D. Candidate (Organic Chemistry)

GAANN Fellow (Graduate Assistance in Areas of National Need)

Advisor: Prof. V. Nair

Dept. of Chemistry, University of Iowa

Iowa City, IA 52242

 

1998

B.S. Chemistry

Dept. of Chemistry, Prairie View A&M University

Prairie View, TX  77446

 

Courses

General Chemistry I (CHEM 107) and Organic Chemistry II (CHEM 201)

 

Research Interests

Eric’s research is in modern synthetic chemistry, the usage of modern state-of-the art analytical instrumentation for full physio-chemical characterization of the properties of new and existing chemical substances, as well as the application of computational, mechanistic, structure - activity relationships to drug design, development and synthesis.

His work in intelligent drug design, synthesis, and evaluation of new and structurally - modified agents is advancing research leading to the discovery of new antiviral, anticancer, and antimalaria drugs which will stop/ reverse cancer or eradicate the etiological agents of malaria and viral diseases. Current work includes

  • C -2, C- 6, and C-8 functionalized ribofuranosyl purine nucleosides as targets against inhibition of Inosine Monophosphate Dehydrogenase (IMPDH) leading to new and improved antiviral, anticancer, antibacterial and immunosuppressive drugs
  • Nucleoside analogue inhibitors against Plasmodium falciprum Thymidylate kinase (PfTMPK) leading to new and improved antimalaria drugs.
  • Synthesis of analogues of Toyocamycin as anticancer chemotherapeutic agents
  • Synthesis of modified indolinones as c-di-AMP synthase inhibitors for antibacterial and anti-biofilm activities

 

Eric works on other projects that involve the evaluation of the effects of select chemicals on certain secondary metabolites of food crops (Metabolomics) as well as bench-top and pilot-scale microbial fermentation and Petroleum Bio-remediation.

 

Professional Memberships

American Chemical Society (ACS)

 

Patents & Publications

Agents that inhibit bacterial biofilm formation. Nira Rabin, Yue Zheng, Clement Opoku-Temeng, Yixuan Du, Eric Bonsu and Herman O. Sintim* Future Med. Chem. 2015, 7: 647-671

Biofilm formation mechanisms and targets for developing anti-biofilm agents. Nira Rabin, Yue Zheng, Clement Opoku-Temeng, Yixuan Du, Eric Bonsu and Herman O. Sintim* Future Med. Chem. 2015, 7: 493-512

Zhang, X. Ma, E. Bonsu, and V. Nair, Base-functionalized carbocyclic nucleosides: design, synthesis, and mechanism of antiviral activity. Nucleosides, Nucleotides & Nucleic Acids, 2009, 28 (5), 408-23.

Nair, V.; Uchil, V.; Ma, X.; Zhu, Q.; Zhang, F.; Bonsu, E. Ribonucleosides Bearing Michael Acceptors: Synthesis, Molecular Docking, Enzyme Inhibition Data and Antiviral Activity, Nucleic Acids Symposium Series, 2008, No. 52 625 – 626.

Nair, V.; Bonsu, E., Gupta, M., Story, S.  Discovery of Antiviral Agents against RNA Viruses: Correlation with Inhibitors of IMPDH, Antiviral Res. 2005, 65, A67.

Story, M. Gupta, E. Bonsu and V. Nair, Inhibitors of Inosine Monophosphate

Dehydrogenase:  Probes for Antiviral Drug Discovery, Nucleosides, Nucleotides &

Nucleic Acids, 2005, 24 (5-7), 717-720.

Nair, S. Story, M. Gupta and E. Bonsu, Antiviral Ribonucleosides: Inhibitors of Inosine

Monophosphate Dehydrogenase, Antiviral Res. 2004, 62, A72.

Story, M. Gupta, E. Bonsu and V. Nair, Inhibitors of Inosine Monophosphate

Dehydrogenase:  Probes for Antiviral Drug Discovery, 16th International Roundtable   

Conference on Nucleosides, Nucleotides and Nucleic Acids, Minneapolis, MN, 2004.

Nair, B. Bera and E. Bonsu, Antiviral Drug Discovery: Inhibitors of Inosine

Monophosphate Dehydrogenase, Georgia Life Sciences Summit 2003, Atlanta, Georgia, 2003.